The Pharmacokinetics of Taurolidine Metabolites in Healthy Volunteers
نویسندگان
چکیده
منابع مشابه
The pharmacokinetics of taurolidine metabolites in healthy volunteers.
Taurolidine is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in human clinical trials. Taurolidine in aqueous solution exists in equilibrium with taurultam. Taurultam is subsequently transformed to taurinamide. The pharmacokinetic profiles of these metabolites are not well established. In this study, 18 healthy volunt...
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Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet. Little is known of the pharmacokinetics of taurine in man after oral administration. We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22-45) following orally administration in the fasting state in the morning. Blood samples were taken at regular intervals an...
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ژورنال
عنوان ژورنال: The Journal of Clinical Pharmacology
سال: 2007
ISSN: 0091-2700
DOI: 10.1177/0091270007299929